Arming parvoviruses with CpG motifs to improve their oncosuppressive capacity

Capacity Building to Improve Hospital Managers’ Performance in West Asia

DNA containing CpG motifs induces angiogenesis.

New blood vessel formation in the cornea is an essential step in the pathogenesis of a blinding immunoinflammatory reaction caused by ocular infection with herpes simplex virus (HSV). By using a murine corneal micropocket assay, we found that HSV DNA (which contains a significant excess of potentially bioactive "CpG" motifs when compared with mammalian DNA) induces angiogenesis. Moreover, synth...

Oncosuppressive functions of decorin

The extracellular matrix is rapidly emerging as a prominent contributor to various fundamental processes of tumorigenesis. In particular, decorin, a member of the small leucine-rich proteoglycan gene family, is assuming a central role as a potent soluble tumor repressor. Decorin binds and antagonizes various receptor tyrosine kinases and inhibits downstream oncogenic signaling in several solid ...

Glucose conjugation of anti-HIV-1 oligonucleotides containing unmethylated CpG motifs reduces their immunostimulatory activity.

Antisense oligodeoxynucleotides (ODNs) are short synthetic DNA polymers complementary to a target RNA sequence. They are commonly designed to halt a biological event, such as translation or splicing. ODNs are potentially useful therapeutic agents for the treatment of different human diseases. Carbohydrate-ODN conjugates have been reported to improve the cell-specific delivery of ODNs through re...

Designing a Management Model for Employee Empowerment with Information Literacy Focus to Improve Their Training

According to the research on information empowerment and information literacy, the purpose of this study was to present an information literacy empowerment model to train the staff of the Central Bank of the Islamic Republic of Iran.Statistical population in the qualitative part of this applied, qualitative-quantitative exploratory and descriptive-correlational study was conducted by academic e...